| Reaction Details |
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 | Report a problem with these data |
| Target | Endoplasmin |
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| Ligand | BDBM50270471 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1708206 (CHEMBL4059439) |
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| Ki | 440±n/a nM |
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| Citation |  Que, NLS; Crowley, VM; Duerfeldt, AS; Zhao, J; Kent, CN; Blagg, BSJ; Gewirth, DT Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding. J Med Chem61:2793-2805 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoplasmin |
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| Name: | Endoplasmin |
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| Synonyms: | ENPL_CANLF | GRP94 | HSP90B1 | Heat shock protein 90 beta | TRA1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 92464.42 |
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| Organism: | Canis familiaris |
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| Description: | ChEMBL_1478277 |
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| Residue: | 804 |
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| Sequence: | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDG
LNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISL
TDENALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNT
LGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAK
EEKEDSDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEDDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD
DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKY
NDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPSDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDE
SEKTKESREAIEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMER
IMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIKDMLRRVKEDEDDKTVSDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETTEDTTEDTEQDDEE
EMDAGTDDEEQETVKKSTAEKDEL
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| BDBM50270471 |
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| n/a |
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| Name | BDBM50270471 |
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| Synonyms: | CHEMBL4075556 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16Cl2N2O2 |
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| Mol. Mass. | 363.238 |
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| SMILES | Oc1cc(O)c(Cl)c(CCc2nccn2Cc2ccccc2)c1Cl |
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| Structure | 
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