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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M3 | ||
| Ligand | BDBM50370682 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1709497 (CHEMBL4119546) | ||
| Ki | 13±n/a nM | ||
| Citation |  Del Bello, F; Bonifazi, A; Giorgioni, G; Petrelli, R; Quaglia, W; Altomare, A; Falcicchio, A; Matucci, R; Vistoli, G; Piergentili, A Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments. Eur J Med Chem137:327-337 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M3 | |||
| Name: | Muscarinic acetylcholine receptor M3 | ||
| Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 66151.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P20309 | ||
| Residue: | 590 | ||
| Sequence: |
| ||
| BDBM50370682 | |||
| n/a | |||
| Name | BDBM50370682 | ||
| Synonyms: | SOLIFENACIN | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H26N2O2 | ||
| Mol. Mass. | 362.4647 | ||
| SMILES | [H]C12CCN(CC1)C[C@@H]2OC(=O)N1CCc2ccccc2[C@@H]1c1ccccc1 |wD:8.10,21.25,TLB:9:8:2.3:6.5,(23.54,-9.18,;23.57,-7.64,;22.04,-8.3,;21.84,-6.92,;23.31,-6.28,;23.38,-4.63,;23.82,-5.74,;24.65,-6.88,;24.94,-8.28,;24.93,-9.81,;23.59,-10.56,;22.26,-9.79,;23.59,-12.1,;24.92,-12.9,;24.88,-14.45,;23.53,-15.19,;23.52,-16.72,;22.17,-17.47,;20.85,-16.68,;20.87,-15.14,;22.21,-14.39,;22.23,-12.84,;20.91,-12.06,;19.57,-12.81,;18.25,-12.02,;18.28,-10.47,;19.62,-9.73,;20.94,-10.52,)| | ||
| Structure | 
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