| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Ligand | BDBM50271776 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1711680 |
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| IC50 | 158±n/a nM |
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| Citation |  Price, DJ; Drewry, DH; Schaller, LT; Thompson, BD; Reid, PR; Maloney, PR; Liang, X; Banker, P; Buckholz, RG; Selley, PK; McDonald, OB; Smith, JL; Shearer, TW; Cox, RF; Williams, SP; Reid, RA; Tacconi, S; Faggioni, F; Piubelli, C; Sartori, I; Tessari, M; Wang, TY An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model. Bioorg Med Chem Lett28:1958-1963 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Name: | Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Synonyms: | 2.7.11.17 | CaM-KK 2 | CaM-KK beta | CaM-kinase kinase 2 | CaM-kinase kinase beta | CaMKK 2 | CaMKK beta | Calcium/calmodulin-dependent protein kinase kinase 2 | Calcium/calmodulin-dependent protein kinase kinase beta | Camkk2 | KKCC2_MOUSE | Kiaa0787 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64610.75 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_118133 |
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| Residue: | 588 |
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| Sequence: | MSSCVSSQPTSDRVAPQDELGSGGGSREGQKPCEALRGLSSLSIHLGMESFIVVTECEPG
RGVDLNLARDQPPEADGQELPLEASDPESRSPLSGRKMSLQEPSQGGPASSSNSLDMNGR
CICPSLSYSPASSPQSSPRMPRRPTVESHHVSITGLQDCVQLNQYTLKDEIGKGSYGVVK
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGARPAPGGCIQPRGPIEQVYQEIAIL
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTREWEPLSEPKEARQRRQP
PGPRAGPCGGGGSALVKGGPCVESWGAPAPGSPPRMPPLQPEEVMEPE
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| BDBM50271776 |
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| n/a |
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| Name | BDBM50271776 |
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| Synonyms: | CHEMBL4125907 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N4O |
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| Mol. Mass. | 370.447 |
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| SMILES | CN(C)Cc1ccc(cc1)-c1cc2c(ccnc2[nH]1)-c1ccc(cc1)C(N)=O |
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| Structure | 
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