| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase PHF2 |
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| Ligand | BDBM92788 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1712928 (CHEMBL4122977) |
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| IC50 | 740000±n/a nM |
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| Citation |  Bhushan, B; Erdmann, A; Zhang, Y; Belle, R; Johannson, C; Oppermann, U; Hopkinson, RJ; Schofield, CJ; Kawamura, A Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases. Bioorg Med Chem26:2984-2991 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase PHF2 |
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| Name: | Lysine-specific demethylase PHF2 |
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| Synonyms: | 1.14.11.- | CENP-35 | GRC5 | KIAA0662 | Lysine-specific demethylase PHF2 | PHD finger protein 2 | PHF2 | PHF2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 120820.94 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117917 |
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| Residue: | 1096 |
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| Sequence: | MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKS
TLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYMEE
HGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDY
YYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLIC
VKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVD
KCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSL
TQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHED
ELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKEEPPSPIEATP
PQSLLEKVSKKKTPKTVKMPKPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASP
TIPNLDLLEAHTKEALTKMEPPKKGKATKSVLSVPNKDVVHMQNDVERLEIREQTKSKSE
AKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPGVFG
ALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTK
PKLDSAAYKSDDSSDEGSLHIDTDTKPGRNARVKKESGSSAAGILDLLQASEEVGALEYN
PSSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGGGSGKS
AGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDNPIFKSRSKKRKGSD
DAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKSAKRKLT
PNTTSPSTSTSISAGTTSTSTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSS
LADHEYTAAGTFTGAQAGRTSQPMAPGVFLTQRRPSASSPNNNTAAKGKRTKKGMATAKQ
RLGKILKIHRNGKLLL
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| BDBM92788 |
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| n/a |
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| Name | BDBM92788 |
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| Synonyms: | WAG-005 |
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| Type | Small molecule |
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| Emp. Form. | C25H30I2NO3 |
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| Mol. Mass. | 646.319 |
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| SMILES | CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCC[N+](C)(C)C)c(I)c1 |
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| Structure | 
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