| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium release-activated calcium channel protein 1 |
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| Ligand | BDBM50273605 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1713065 (CHEMBL4123114) |
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| IC50 | 89000±n/a nM |
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| Citation |  Stevenson, RJ; Azimi, I; Flanagan, JU; Inserra, M; Vetter, I; Monteith, GR; Denny, WA An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca Bioorg Med Chem26:3406-3413 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium release-activated calcium channel protein 1 |
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| Name: | Calcium release-activated calcium channel protein 1 |
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| Synonyms: | CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A |
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| Type: | Protein |
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| Mol. Mass.: | 32676.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96D31 |
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| Residue: | 301 |
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| Sequence: | MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY
SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL
IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST
VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST
TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY
A
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| BDBM50273605 |
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| n/a |
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| Name | BDBM50273605 |
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| Synonyms: | CHEMBL4127069 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14F3N3O4 |
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| Mol. Mass. | 393.3167 |
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| SMILES | OC1(CC(=NN1C(=O)Cc1ccccc1)c1cccc(c1)[N+]([O-])=O)C(F)(F)F |c:3| |
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| Structure | 
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