Reaction Details |
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Target | Renin |
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Ligand | BDBM50014049 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_195939 |
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IC50 | 2.3±n/a nM |
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Citation | Rosenberg, SH; Dellaria, JF; Kempf, DJ; Hutchins, CW; Woods, KW; Maki, RG; de Lara, E; Spina, KP; Stein, HH; Cohen, J Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site. J Med Chem33:1582-90 (1990) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50014049 |
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n/a |
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Name | BDBM50014049 |
Synonyms: | CHEMBL287953 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy-2-(4-methyl-5-oxo-tetrahydro-furan-2-yl)-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester |
Type | Small organic molecule |
Emp. Form. | C34H49N5O7 |
Mol. Mass. | 639.7822 |
SMILES | C[C@H]1C[C@H](OC1=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C |
Structure |
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