| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
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| Ligand | BDBM50014188 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_141140 (CHEMBL749040) |
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| Ki | 1400±n/a nM |
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| Citation |  Subasinghe, N; Schulte, M; Chan, MY; Roon, RJ; Koerner, JF; Johnson, RL Synthesis of acyclic and dehydroaspartic acid analogues of Ac-Asp-Glu-OH and their inhibition of rat brain N-acetylated alpha-linked acidic dipeptidase (NAALA dipeptidase). J Med Chem33:2734-44 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate carboxypeptidase 2 |
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| Name: | Glutamate carboxypeptidase 2 |
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| Synonyms: | FOLH1_RAT | Folh1 | Glutamate carboxypeptidase II | Naalad1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84547.28 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_68365 |
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| Residue: | 752 |
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| Sequence: | MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMK
KAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLS
YPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVN
YARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPG
VKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIG
YDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNV
IGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILF
ASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLT
KELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYT
KNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQ
SYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNP
ILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNK
VDTSKAWREVKRQISIAAFTVQAAAETLREVD
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| BDBM50014188 |
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| n/a |
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| Name | BDBM50014188 |
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| Synonyms: | 2-(3-Carboxy-2-methoxycarbonylamino-acryloylamino)-pentanedioic acid | CHEMBL93737 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H14N2O9 |
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| Mol. Mass. | 318.2369 |
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| SMILES | COC(=O)N=C(CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |w:4.3| |
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| Structure | 
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