| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin beta chain |
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| Ligand | BDBM50014846 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1713861 (CHEMBL4123910) |
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| IC50 | 6930±n/a nM |
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| Citation |  Batran, RZ; Kassem, AF; Abbas, EMH; Elseginy, SA; Mounier, MM Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells. Bioorg Med Chem26:3474-3490 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin beta chain |
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| Name: | Tubulin beta chain |
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| Synonyms: | TBB5_HUMAN | TUBB | TUBB5 | TUBB5 | Tubulin beta chain | Tubulin beta-5 chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49650.12 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117191 |
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| Residue: | 444 |
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| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDFGEEAEEEA
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| BDBM50014846 |
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| n/a |
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| Name | BDBM50014846 |
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| Synonyms: | (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide | (S)-colchicine | 7alphaH-colchicine | CHEMBL107 | COLCHICINE | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide | colchicina | colchicinum |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25NO6 |
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| Mol. Mass. | 399.437 |
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| SMILES | COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC |r| |
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| Structure | 
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