| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin beta chain |
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| Ligand | BDBM50274080 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1713861 (CHEMBL4123910) |
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| IC50 | 9370±n/a nM |
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| Citation |  Batran, RZ; Kassem, AF; Abbas, EMH; Elseginy, SA; Mounier, MM Design, synthesis and molecular modeling of new 4-phenylcoumarin derivatives as tubulin polymerization inhibitors targeting MCF-7 breast cancer cells. Bioorg Med Chem26:3474-3490 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin beta chain |
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| Name: | Tubulin beta chain |
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| Synonyms: | TBB5_HUMAN | TUBB | TUBB5 | TUBB5 | Tubulin beta chain | Tubulin beta-5 chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49650.12 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117191 |
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| Residue: | 444 |
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| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDFGEEAEEEA
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| BDBM50274080 |
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| n/a |
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| Name | BDBM50274080 |
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| Synonyms: | CHEMBL4129198 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H19FN2O5S |
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| Mol. Mass. | 490.503 |
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| SMILES | Fc1ccc(cc1)C1SCC(=O)N1NC(=O)COc1ccc2c(cc(=O)oc2c1)-c1ccccc1 |
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| Structure | 
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