| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM50274882 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1714355 (CHEMBL4124404) |
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| IC50 | 6100±n/a nM |
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| Citation |  Taha, M; Rashid, U; Imran, S; Ali, M Rational design of bis-indolylmethane-oxadiazole hybrids as inhibitors of thymidine phosphorylase. Bioorg Med Chem26:3654-3663 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | TYPH_ECOLI | TdRPase | Thymidine Phosphorylase (TP) | deoA | tpp | ttg |
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| Type: | Enzyme |
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| Mol. Mass.: | 47198.54 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 440 |
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| Sequence: | MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLT
MAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHT
GGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSI
PLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLT
DMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKL
QAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALG
MAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAA
IKLADKAPESTPTVYRRISE
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| BDBM50274882 |
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| n/a |
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| Name | BDBM50274882 |
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| Synonyms: | CHEMBL4129587 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H20Cl2N4O3 |
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| Mol. Mass. | 567.422 |
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| SMILES | Oc1ccc(O)c(c1)-c1nnc(o1)-c1ccc(cc1)C(c1c[nH]c2ccc(Cl)cc12)c1c[nH]c2ccc(Cl)cc12 |
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| Structure | 
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