| Reaction Details |
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 | Report a problem with these data |
| Target | Glucagon-like peptide 1 receptor |
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| Ligand | BDBM50275545 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1714751 (CHEMBL4124800) |
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| EC50 | 0.002200±n/a nM |
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| Citation |  Evers, A; Bossart, M; Pfeiffer-Marek, S; Elvert, R; Schreuder, H; Kurz, M; Stengelin, S; Lorenz, M; Herling, A; Konkar, A; Lukasczyk, U; Pfenninger, A; Lorenz, K; Haack, T; Kadereit, D; Wagner, M Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations. J Med Chem61:5580-5593 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucagon-like peptide 1 receptor |
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| Name: | Glucagon-like peptide 1 receptor |
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| Synonyms: | GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53035.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43220 |
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| Residue: | 463 |
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| Sequence: | MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
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| BDBM50275545 |
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| n/a |
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| Name | BDBM50275545 |
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| Synonyms: | CHEMBL4126953 |
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| Type | Small organic molecule |
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| Emp. Form. | C211H332N54O64 |
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| Mol. Mass. | 4649.2172 |
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| SMILES | CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O)C(O)=O)C(O)=O |r| |
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| Structure | 
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