| Reaction Details |
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 | Report a problem with these data |
| Target | Glucagon-like peptide 1 receptor |
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| Ligand | BDBM50275565 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1714761 (CHEMBL4124810) |
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| EC50 | 0.004100±n/a nM |
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| Citation |  Evers, A; Bossart, M; Pfeiffer-Marek, S; Elvert, R; Schreuder, H; Kurz, M; Stengelin, S; Lorenz, M; Herling, A; Konkar, A; Lukasczyk, U; Pfenninger, A; Lorenz, K; Haack, T; Kadereit, D; Wagner, M Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations. J Med Chem61:5580-5593 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucagon-like peptide 1 receptor |
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| Name: | Glucagon-like peptide 1 receptor |
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| Synonyms: | GLP1R | Glucagon-like peptide 1 receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52947.60 |
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| Organism: | Macaca fascicularis |
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| Description: | ChEMBL_117790 |
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| Residue: | 463 |
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| Sequence: | MAGTPGPLRLALLLLGVVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRVVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVFSEQRIFRLYVSVGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
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| BDBM50275565 |
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| n/a |
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| Name | BDBM50275565 |
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| Synonyms: | CHEMBL4125912 |
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| Type | Small organic molecule |
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| Emp. Form. | C173H267N43O51 |
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| Mol. Mass. | 3765.2286 |
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| SMILES | CCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| |
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| Structure | 
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