Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50041558 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1715426 (CHEMBL4125475) |
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Ki | 5.2±n/a nM |
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Citation | Skogh, A; Lesniak, A; Sköld, C; Karlgren, M; Gaugaz, FZ; Svensson, R; Diwakarla, S; Jonsson, A; Fransson, R; Nyberg, F; Hallberg, M; Sandström, A An imidazole based H-Phe-Phe-NH Bioorg Med Chem Lett28:2446-2450 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46371.54 |
Organism: | Rattus norvegicus (rat) |
Description: | Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor. |
Residue: | 407 |
Sequence: | MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAH
KRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTIST
VVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
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BDBM50041558 |
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n/a |
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Name | BDBM50041558 |
Synonyms: | CHEMBL2042018 |
Type | Small organic molecule |
Emp. Form. | C17H18N2O3 |
Mol. Mass. | 298.3364 |
SMILES | NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r| |
Structure |
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