| Reaction Details |
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 | Report a problem with these data |
| Target | Ectonucleoside triphosphate diphosphohydrolase 8 |
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| Ligand | BDBM50276781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1716387 |
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| IC50 | >300000±n/a nM |
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| Citation |  Kuhrt, D; Ejaz, SA; Afzal, S; Khan, SU; Lecka, J; Sévigny, J; Ehlers, P; Spannenberg, A; Iqbal, J; Langer, P Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors. Eur J Med Chem138:816-829 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ectonucleoside triphosphate diphosphohydrolase 8 |
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| Name: | Ectonucleoside triphosphate diphosphohydrolase 8 |
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| Synonyms: | ENTP8_HUMAN | ENTPD8 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53895.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_514295 |
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| Residue: | 495 |
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| Sequence: | MGLSRKEQVFLALLGASGVSGLTALILLLVEATSVLLPTDIKFGIVFDAGSSHTSLFLYQ
WLANKENGTGVVSQALACQVEGPGISSYTSNAAQAGESLQGCLEEALVLIPEAQHRKTPT
FLGATAGMRLLSRKNSSQARDIFAAVTQVLGRSPVDFWGAELLAGQAEGAFGWITVNYGL
GTLVKYSFTGEWIQPPEEMLVGALDMGGASTQITFVPGGPILDKSTQADFRLYGSDYSVY
THSYLCFGRDQMLSRLLVGLVQSRPAALLRHPCYLSGYQTTLALGPLYESPCVHATPPLS
LPQNLTVEGTGNPGACVSAIRELFNFSSCQGQEDCAFDGVYQPPLRGQFYAFSNFYYTFH
FLNLTSRQPLSTVNATIWEFCQRPWKLVEASYPGQDRWLRDYCASGLYILTLLHEGYGFS
EETWPSLEFRKQAGGVDIGWTLGYMLNLTGMIPADAPAQWRAESYGVWVAKVVFMVLALV
AVVGAALVQLFWLQD
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| BDBM50276781 |
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| n/a |
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| Name | BDBM50276781 |
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| Synonyms: | CHEMBL4159729 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H24F3N |
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| Mol. Mass. | 467.5242 |
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| SMILES | Cc1cccc(c1)-c1cccc2c(-c3cccc(C)c3)c(-c3cccc(C)c3)c(nc12)C(F)(F)F |
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| Structure | 
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