Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase type 2 | ||
Ligand | BDBM50277203 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_1717701 | ||
IC50 | 100±n/a nM | ||
Citation | Leiva, R; Griñan-Ferré, C; Seira, C; Valverde, E; McBride, A; Binnie, M; Pérez, B; Luque, FJ; Pallàs, M; Bidon-Chanal, A; Webster, SP; Vázquez, S Design, synthesis and in vivo study of novel pyrrolidine-based 11?-HSD1 inhibitors for age-related cognitive dysfunction. Eur J Med Chem139:412-428 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase type 2 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase type 2 | ||
Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 | ||
Type: | Enzyme | ||
Mol. Mass.: | 44141.72 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Purified recombinant human 11beta-HSD2. | ||
Residue: | 405 | ||
Sequence: |
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BDBM50277203 | |||
n/a | |||
Name | BDBM50277203 | ||
Synonyms: | CHEMBL4170932 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H27NO | ||
Mol. Mass. | 261.4024 | ||
SMILES | O=C(C1CCCCC1)N1CC2C(C1)C1CCC2CC1 |TLB:9:10:15.14:17.18,12:11:15.14:17.18,(11.97,-36.21,;11.94,-34.68,;13.26,-33.89,;14.6,-34.64,;15.91,-33.86,;15.9,-32.32,;14.55,-31.57,;13.23,-32.36,;10.6,-33.93,;9.04,-33.74,;8.64,-32.35,;9.4,-30.93,;9.64,-32.74,;7.7,-30.37,;6.13,-31.11,;5.44,-32.57,;7.11,-31.74,;6.73,-30.35,;7.25,-28.69,)| | ||
Structure |