| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 3 |
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| Ligand | BDBM50278662 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1719035 (CHEMBL4134035) |
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| IC50 | 245±n/a nM |
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| Citation |  Engers, JL; Bollinger, KA; Weiner, RL; Rodriguez, AL; Long, MF; Breiner, MM; Chang, S; Bollinger, SR; Bubser, M; Jones, CK; Morrison, RD; Bridges, TM; Blobaum, AL; Niswender, CM; Conn, PJ; Emmitte, KA; Lindsley, CW Design and Synthesis of ACS Med Chem Lett8:925-930 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 3 |
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| Name: | Metabotropic glutamate receptor 3 |
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| Synonyms: | GRM3_RAT | Gprc1c | Grm3 | Mglur3 | glutamate receptor, metabotropic 3 precursor |
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| Type: | Protein |
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| Mol. Mass.: | 98971.84 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P31422 |
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| Residue: | 879 |
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| Sequence: | MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVAS
DGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSY
LKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
VDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIK
HNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLP
EKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLH
LNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL
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| BDBM50278662 |
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| n/a |
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| Name | BDBM50278662 |
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| Synonyms: | CHEMBL4172540 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18FNO3 |
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| Mol. Mass. | 339.3602 |
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| SMILES | C[C@@H](COc1ccn(-c2ccc(F)cc2)c(=O)c1)Oc1ccccc1 |r| |
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| Structure | 
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