| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
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| Ligand | BDBM50378979 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1719304 (CHEMBL4134304) |
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| IC50 | 5.0±n/a nM |
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| Citation |  Kindon, N; Andrews, G; Baxter, A; Cheshire, D; Hemsley, P; Johnson, T; Liu, YZ; McGinnity, D; McHale, M; Mete, A; Reuberson, J; Roberts, B; Steele, J; Teobald, B; Unitt, J; Vaughan, D; Walters, I; Stocks, MJ Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS Med Chem Lett8:981-986 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 4 |
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| Name: | C-C chemokine receptor type 4 |
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| Synonyms: | C-C CKR-4 | CC-CKR-4 | CCR-4 | CCR4_MOUSE | CD_antigen=CD194 | Ccr4 | Cmkbr4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41410.76 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_512157 |
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| Residue: | 360 |
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| Sequence: | MNATEVTDTTQDETVYNSYYFYESMPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVV
VLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIVSWMYLVG
FYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYT
EHNHTYCKTQYSVNSTTWKVLSSLEINVLGLLIPLGIMLFCYSMIIRTLQHCKNEKKNRA
VRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLN
PVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFLQVYSADMSSSSYTQSTVDHDFRDAL
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| BDBM50378979 |
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| n/a |
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| Name | BDBM50378979 |
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| Synonyms: | CHEMBL2011441 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H7BrClN3O3S2 |
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| Mol. Mass. | 384.657 |
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| SMILES | COc1nc(Br)cnc1NS(=O)(=O)c1ccc(Cl)s1 |
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| Structure | 
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