| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
|---|
| Ligand | BDBM50278724 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1719317 (CHEMBL4134317) |
|---|
| IC50 | 25±n/a nM |
|---|
| Citation |  Kindon, N; Andrews, G; Baxter, A; Cheshire, D; Hemsley, P; Johnson, T; Liu, YZ; McGinnity, D; McHale, M; Mete, A; Reuberson, J; Roberts, B; Steele, J; Teobald, B; Unitt, J; Vaughan, D; Walters, I; Stocks, MJ Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS Med Chem Lett8:981-986 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 4 |
|---|
| Name: | C-C chemokine receptor type 4 |
|---|
| Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | CC-CKR-4 | CCR-4 | CCR4 | CCR4_CANLF |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 41361.83 |
|---|
| Organism: | Canis lupus familiaris |
|---|
| Description: | ChEMBL_118144 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MNPTDIADTTLDESIYNNYYLYENIPKPCTKEGIKAFGELFLPPLYSLVFLFGLLGNSVV
VVVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIISWMYLVG
FYSGIFFIMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVLASLPGLLFSTCYT
ERNHTYCKTKYSRNSTRWKVLSSLEINILGLVIPLGTMLFCYSMIIRTLQHCKNEKKSKA
VRMVFAVVALFLGFWAPYNVVLFLETLVELEVLQDCTFERHLDYAIQATETLAFVHCCLN
PVIYFFLGEKFRKYLVQLFKTCRGPFMLCQYCRLLQMYSPDTPSSSYTQSTGDHDLHDAL
|
|
|
|---|
| BDBM50278724 |
|---|
| n/a |
|---|
| Name | BDBM50278724 |
|---|
| Synonyms: | CHEMBL4169247 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H9Cl2N3O3S |
|---|
| Mol. Mass. | 334.178 |
|---|
| SMILES | COc1nccnc1NS(=O)(=O)c1cccc(Cl)c1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
