| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM8370 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1720736 (CHEMBL4135736) |
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| IC50 | 501±n/a nM |
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| Citation |  Henley, ZA; Bax, BD; Inglesby, LM; Champigny, A; Gaines, S; Faulder, P; Le, J; Thomas, DA; Washio, Y; Baldwin, IR From PIM1 to PI3K? via GSK3?: Target Hopping through the Kinome. ACS Med Chem Lett8:1093-1098 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM8370 |
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| n/a |
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| Name | BDBM8370 |
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| Synonyms: | N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropanecarboxamide | indazole analogue 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15N3O2 |
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| Mol. Mass. | 293.3199 |
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| SMILES | Oc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1 |
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| Structure | 
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