| Reaction Details |
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 | Report a problem with these data |
| Target | Cystathionine gamma-lyase |
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| Ligand | BDBM50280012 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1721616 |
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| IC50 | 6000±n/a nM |
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| Citation |  Bhattacharjee, A; Sinha, A; Ratia, K; Yin, L; Delgado-Rivera, L; Petukhov, PA; Thatcher, GRJ; Wardrop, DJ 2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine ?-Lyase (CSE). ACS Med Chem Lett8:1241-1245 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cystathionine gamma-lyase |
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| Name: | Cystathionine gamma-lyase |
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| Synonyms: | CGL_HUMAN | CTH | Cystathionine gamma-lyase (CSE) | Cysteine-protein sulfhydrase | Gamma-cystathionase |
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| Type: | Protein |
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| Mol. Mass.: | 44509.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32929 |
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| Residue: | 405 |
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| Sequence: | MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEY
SRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRY
FRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHG
DIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQ
NSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQH
ELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVL
KNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
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| BDBM50280012 |
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| n/a |
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| Name | BDBM50280012 |
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| Synonyms: | CHEMBL4174491 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12F4N4OS2 |
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| Mol. Mass. | 416.416 |
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| SMILES | Fc1cccnc1\C=N\NC(=S)SCC(=O)Nc1ccc(cc1)C(F)(F)F |
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| Structure | 
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