| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock cognate 71 kDa protein |
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| Ligand | BDBM50281174 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1722426 (CHEMBL4137426) |
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| Kd | 13780±n/a nM |
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| Citation |  Shao, H; Li, X; Moses, MA; Gilbert, LA; Kalyanaraman, C; Young, ZT; Chernova, M; Journey, SN; Weissman, JS; Hann, B; Jacobson, MP; Neckers, L; Gestwicki, JE Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). J Med Chem61:6163-6177 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heat shock cognate 71 kDa protein |
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| Name: | Heat shock cognate 71 kDa protein |
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| Synonyms: | HSC70 | HSP73 | HSP7C_HUMAN | HSPA10 | HSPA8 | heat shock 70kDa protein 8 isoform 1 | heat shock 70kDa protein 8 isoform 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 70887.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_5729877 |
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| Residue: | 646 |
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| Sequence: | MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
MNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVS
SMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAA
IAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNH
FIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRA
RFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELN
KSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTI
PTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDI
DANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKN
SLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELE
KVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
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| BDBM50281174 |
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| n/a |
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| Name | BDBM50281174 |
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| Synonyms: | CHEMBL4168736 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18BrClF3N3O2S3 |
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| Mol. Mass. | 636.955 |
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| SMILES | [Cl-].CCn1\c(=C\c2scc[n+]2Cc2ccc(o2)C(F)(F)F)s\c(=C2\Sc3cc(Br)ccc3N2C)c1=O |
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| Structure | 
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