| Reaction Details |
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 | Report a problem with these data |
| Target | Kelch-like ECH-associated protein 1 |
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| Ligand | BDBM50283797 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1726329 (CHEMBL4141607) |
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| Kd | 6.2±n/a nM |
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| Citation |  Lu, MC; Jiao, Q; Liu, T; Tan, SJ; Zhou, HS; You, QD; Jiang, ZY Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency. Eur J Med Chem143:1578-1589 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kelch-like ECH-associated protein 1 |
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| Name: | Kelch-like ECH-associated protein 1 |
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| Synonyms: | Cytosolic inhibitor of Nrf2 | INRF2 | KEAP1 | KEAP1/Cullin-3/Microtubule-associated protein tau | KEAP1_HUMAN | KIAA0132 | KLHL19 | Kelch-like protein 19 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69664.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107924 |
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| Residue: | 624 |
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| Sequence: | MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
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| BDBM50283797 |
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| n/a |
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| Name | BDBM50283797 |
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| Synonyms: | CHEMBL4169002 |
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| Type | Small organic molecule |
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| Emp. Form. | C53H78N12O19 |
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| Mol. Mass. | 1187.2554 |
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| SMILES | [H][C@@]12CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@]([H])(NC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O |r| |
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| Structure | 
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