| Reaction Details |
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 | Report a problem with these data |
| Target | Pantothenate kinase 1, putative |
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| Ligand | BDBM50285608 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1728593 (CHEMBL4143871) |
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| IC50 | 140±n/a nM |
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| Citation |  Spry, C; Sewell, AL; Hering, Y; Villa, MVJ; Weber, J; Hobson, SJ; Harnor, SJ; Gul, S; Marquez, R; Saliba, KJ Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation. Eur J Med Chem143:1139-1147 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pantothenate kinase 1, putative |
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| Name: | Pantothenate kinase 1, putative |
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| Synonyms: | 2.7.1.33 | Pantothenate kinase, putative |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59927.32 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_117866 |
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| Residue: | 519 |
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| Sequence: | MRKYKNELNISNVLEKKDDCCSLDIGGTLIKVVYVNHKYIHDDNIKENTEHLMIKMNGNK
NIYLTFFDISKLDDTLYFLLRNNLIKKKITLTGGGAHKYFYHVLEKALYHKLGMEINKGD
NKIYVSKYLYDEKLSIFSIFVCSTKSNDQNKNDDINNFNSKIIEGQVLFDKKFVDKFPSD
TIKIYVEKRYFDKNGNNDDNNNDDDDNNDDDNNNNDDNNNDNYMILTCSRKDEMNCIMNG
IHTLFSVDKSFFRYERFLNVKVPVKITSPFHPFIIANIGSGISILKSNGYDSYQRIAGTA
IGGGTLMGLAKIILDNISFEELIKCAEDKNKNISFDLKMKHIIGDAPVDGCTHANTLASC
FGCLKNILKEIKENNGHNKTIHHEVAKGLIQMVSYNIGYMVYLLSKMHNVKRIFFSGKYI
SNNEYIMESLTHGVYYYYLHFNSKMNGVDKINDINLKNNIAKNTIKRELYNVKDIHFNDK
DMNSYLSYHYKLQDKEILPQVLFPKHDGFLGALGCFFLA
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| BDBM50285608 |
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| n/a |
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| Name | BDBM50285608 |
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| Synonyms: | CHEMBL4167606 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21NO5 |
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| Mol. Mass. | 307.3416 |
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| SMILES | CC(C)(CO)[C@@H](O)C(=O)N\C=C\C(=O)OCc1ccccc1 |r| |
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| Structure | 
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