| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM50016641 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_157077 |
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| IC50 | 580±n/a nM |
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| Citation |  Rizzi, JP; Schnur, RC; Hutson, NJ; Kraus, KG; Kelbaugh, PR Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors. J Med Chem32:1208-13 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR) |
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| Type: | Protein |
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| Mol. Mass.: | 35855.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0 |
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| Residue: | 316 |
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| Sequence: | MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
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| BDBM50016641 |
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| n/a |
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| Name | BDBM50016641 |
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| Synonyms: | 5-(5-Chloro-2-methanesulfonyl-3-trifluoromethyl-phenyl)-imidazolidine-2,4-dione | CHEMBL440790 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H8ClF3N2O4S |
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| Mol. Mass. | 356.705 |
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| SMILES | CS(=O)(=O)c1c(cc(Cl)cc1C(F)(F)F)-c1[nH]c(=O)[nH]c1O |
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| Structure | 
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