| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Ligand | BDBM50016687 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_219 |
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| IC50 | 500±n/a nM |
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| Citation |  Huang, FC; Shoupe, TS; Lin, CJ; Lee, TD; Chan, WK; Tan, J; Schnapper, M; Suh, JT; Gordon, RJ; Sonnino, PA Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis. J Med Chem32:1836-42 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Synonyms: | 12-LOX | 12/15-lipoxygenase | 15-LOX | Alox12l | Alox15 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, leukocyte-type | Arachidonate omega-6 lipoxygenase | LOX15_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 75377.59 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1510006 |
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| Residue: | 663 |
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| Sequence: | MGVYRIRVSTGDSKYAGSNNEVYLWLVGQHGEASLGKLLRPCRDSEAEFKVDVSEYLGPL
LFVRVQKWHYLTDDAWFCNWISVKGPGDQGSEYMFPCYRWVQGRSILSLPEGTGCTVVED
SQGLFRKHREEELEERRSLYRWGNWKDGSILNVAAASISDLPVDQRFREDKRIEFEASQV
IGVMDTVVNFPINTVTCWKSLDDFNCVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPM
VLKRSTCLPARLVFPPGMEKLQAQLNKELQKGTLFEADFFLLDGIKANVILCSQQYLAAP
LVMLKLMPDGQLLPIAIQLELPKTGSTPPPIFTPSDPPMDWLLAKCWVRSSDLQLHELQA
HLLRGHLMAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKAMS
TGGGGHLDLLKQAGAFLTYCSLCPPDDLAERGLLDIETCFYAKDALRLWQIMNRYVVGMF
NLHYKTDKAVQDDYELQSWCREITDIGLQGAQDRGFPTSLQSRAQACYFITMCIFTCTAQ
HSSVHLGQLDWFYWVPNAPCTMRLPPPTTKEATMEKLMATLPNPNQSTLQINVVWLLGRR
QAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSMVENS
VAI
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|
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| BDBM50016687 |
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| n/a |
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| Name | BDBM50016687 |
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| Synonyms: | 2-(4-Benzyloxy-phenyl)-N-hydroxy-N-methyl-acetamide | CHEMBL54453 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17NO3 |
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| Mol. Mass. | 271.3111 |
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| SMILES | CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1 |
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| Structure | 
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