| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50290154 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1730616 (CHEMBL4146152) |
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| IC50 | 30±n/a nM |
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| Citation |  Yang, X; Wedajo, W; Yamada, Y; Dahlroth, SL; Neo, JJ; Dick, T; Chui, WK 1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity. Eur J Med Chem144:262-276 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MYCTU | dfrA | folA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 17872.62 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_102873 |
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| Residue: | 161 |
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| Sequence: | MTMVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLP
GRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIG
LPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS
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| BDBM50290154 |
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| n/a |
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| Name | BDBM50290154 |
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| Synonyms: | CHEMBL3245817 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N8O5 |
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| Mol. Mass. | 510.5456 |
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| SMILES | CCOC(=O)CC[C@H](NC(=O)c1ccc(cc1)N(C)Cc1cnc2nc(N)nc(N)c2n1)C(=O)OCC |r| |
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| Structure | 
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