| Reaction Details |
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 | Report a problem with these data |
| Target | rRNA adenine N-6-methyltransferase |
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| Ligand | BDBM50291836 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1731826 (CHEMBL4147362) |
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| Ki | 110900±n/a nM |
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| Citation |  Foik, IP; Tuszynska, I; Feder, M; Purta, E; Stefaniak, F; Bujnicki, JM Novel inhibitors of the rRNA ErmC' methyltransferase to block resistance to macrolides, lincosamides, streptogramine B antibiotics. Eur J Med Chem146:60-67 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| rRNA adenine N-6-methyltransferase |
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| Name: | rRNA adenine N-6-methyltransferase |
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| Synonyms: | 2.1.1.184 | ERMA_STAAN | Erythromycin resistance protein | Macrolide-lincosamide-streptogramin B resistance protein | ermA1 | ermA2 | ermA3 | ermA4 | ermA5 | rRNA adenine N-6-methyltransferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 28433.06 |
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| Organism: | Staphylococcus aureus (strain N315) |
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| Description: | ChEMBL_117813 |
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| Residue: | 243 |
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| Sequence: | MNQKNPKDTQNFITSKKHVKEILNHTNISKQDNVIEIGSGKGHFTKELVKMSRSVTAIEI
DGGLCQVTKEAVNPSENIKVIQTDILKFSFPKHINYKIYGNIPYNISTDIVKRITFESQA
KYSYLIVEKGFAKRLQNLQRALGLLLMVEMDIKMLKKVPPLYFHPKPSVDSVLIVLERHQ
PLISKKDYKKYRSFVYKWVNREYRVLFTKNQFRQALKHANVTNINKLSKEQFLSIFNSYK
LFH
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| BDBM50291836 |
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| n/a |
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| Name | BDBM50291836 |
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| Synonyms: | CHEMBL4177311 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16F3N7OS |
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| Mol. Mass. | 435.426 |
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| SMILES | FC(F)(F)c1ccc(nc1)N1CCN(CC1)C(=O)c1csc(Nc2ncccn2)n1 |
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| Structure | 
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