Reaction Details |
| Report a problem with these data |
Target | rRNA adenine N-6-methyltransferase |
---|
Ligand | BDBM50292283 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1731823 (CHEMBL4147359) |
---|
IC50 | 500000±n/a nM |
---|
Citation | Foik, IP; Tuszynska, I; Feder, M; Purta, E; Stefaniak, F; Bujnicki, JM Novel inhibitors of the rRNA ErmC' methyltransferase to block resistance to macrolides, lincosamides, streptogramine B antibiotics. Eur J Med Chem146:60-67 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
rRNA adenine N-6-methyltransferase |
---|
Name: | rRNA adenine N-6-methyltransferase |
Synonyms: | 2.1.1.184 | ERMA_STAAN | Erythromycin resistance protein | Macrolide-lincosamide-streptogramin B resistance protein | ermA1 | ermA2 | ermA3 | ermA4 | ermA5 | rRNA adenine N-6-methyltransferase |
Type: | PROTEIN |
Mol. Mass.: | 28433.06 |
Organism: | Staphylococcus aureus (strain N315) |
Description: | ChEMBL_117813 |
Residue: | 243 |
Sequence: | MNQKNPKDTQNFITSKKHVKEILNHTNISKQDNVIEIGSGKGHFTKELVKMSRSVTAIEI
DGGLCQVTKEAVNPSENIKVIQTDILKFSFPKHINYKIYGNIPYNISTDIVKRITFESQA
KYSYLIVEKGFAKRLQNLQRALGLLLMVEMDIKMLKKVPPLYFHPKPSVDSVLIVLERHQ
PLISKKDYKKYRSFVYKWVNREYRVLFTKNQFRQALKHANVTNINKLSKEQFLSIFNSYK
LFH
|
|
|
BDBM50292283 |
---|
n/a |
---|
Name | BDBM50292283 |
Synonyms: | CHEMBL4166273 |
Type | Small organic molecule |
Emp. Form. | C17H15FN4O |
Mol. Mass. | 310.3256 |
SMILES | Cn1cnnc1-c1cccc(NC(=O)Cc2cccc(F)c2)c1 |
Structure |
|