| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2E1 |
|---|
| Ligand | BDBM50366398 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1735371 (CHEMBL4150907) |
|---|
| IC50 | 15000±n/a nM |
|---|
| Citation |  Denton, TT; Srivastava, P; Xia, Z; Chen, G; Watson, CJW; Wynd, A; Lazarus, P Identification of the 4-Position of 3-Alkynyl and 3-Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P-450 2A6 Inhibition. J Med Chem61:7065-7086 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2E1 |
|---|
| Name: | Cytochrome P450 2E1 |
|---|
| Synonyms: | CP2E1_HUMAN | CYP2E | CYP2E1 | Cytochrome P450 2E1 (CYP2E1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56860.34 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05181 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL
AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP
TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI
ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA
EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
TETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRF
ITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGK
FKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGC
IPPRYKLCVIPRS
|
|
|
|---|
| BDBM50366398 |
|---|
| n/a |
|---|
| Name | BDBM50366398 |
|---|
| Synonyms: | CHEMBL4164113 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H14Cl2N2 |
|---|
| Mol. Mass. | 281.18 |
|---|
| SMILES | Cl.Cl.NCC#Cc1cnccc1-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
