| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Excitatory amino acid transporter 4 |
|---|
| Ligand | BDBM18125 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1735433 (CHEMBL4150969) |
|---|
| IC50 | 11000±n/a nM |
|---|
| Citation |  Fu, H; Zhang, J; Tepper, PG; Bunch, L; Jensen, AA; Poelarends, GJ Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors. J Med Chem61:7741-7753 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Excitatory amino acid transporter 4 |
|---|
| Name: | Excitatory amino acid transporter 4 |
|---|
| Synonyms: | EAA4_RAT | Eaat4 | Excitatory amino acid transporter 4 | High-affinity neuronal glutamate transporter | Slc1a6 | Sodium-dependent glutamate/aspartate transporter | Solute carrier family 1 member 6 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60724.56 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_100180 |
|---|
| Residue: | 561 |
|---|
| Sequence: | MSSHGNSLFLRESGAGGGCLQGLQDSLQQRALRTRLRLQTMTREHVRRFLRRNAFILLTV
SAVIIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSRVTGMASLDNKA
TGRMGMRAAVYYMVTTVIAVFIGILMVTIIHPGKGSKEGLHREGRIETVPTADAFMDLVR
NMFPPNLVEACFKQFKTQYSTRVVTRTIVRTDNGSELGASISPPSSAENETSILENVTRA
LGTLQEVISFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAI
MRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGGVLPLIYF
LVTHRNPFPFIGGILQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVN
MDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSV
GLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLGKPY
KSLMAQAKGASRGRGGNESVM
|
|
|
|---|
| BDBM18125 |
|---|
| n/a |
|---|
| Name | BDBM18125 |
|---|
| Synonyms: | (2S)-2-aminobutanedioic acid | Aspartate | CHEMBL274323 | L-Aspartate | L-Aspartic acid, 2 | L-[14C]aspartate |
|---|
| Type | Amino Acid |
|---|
| Emp. Form. | C4H7NO4 |
|---|
| Mol. Mass. | 133.1027 |
|---|
| SMILES | N[C@@H](CC(O)=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
