| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Catechol O-methyltransferase |
|---|
| Ligand | BDBM50017846 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_47065 |
|---|
| IC50 | 12±n/a nM |
|---|
| Citation |  Bäckström, R; Honkanen, E; Pippuri, A; Kairisalo, P; Pystynen, J; Heinola, K; Nissinen, E; Linden, IB; Männistö, PT; Kaakkola, S Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors. J Med Chem32:841-6 (1989) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Catechol O-methyltransferase |
|---|
| Name: | Catechol O-methyltransferase |
|---|
| Synonyms: | COMT_RAT | Catechol O-methyltransferase | Catechol-O-methyltransferase | Comt |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29594.09 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 264 |
|---|
| Sequence: | MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNA
KPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMA
RLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDM
VFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSY
LEYMKVVDGLEKAIYQGPSSPDKS
|
|
|
|---|
| BDBM50017846 |
|---|
| n/a |
|---|
| Name | BDBM50017846 |
|---|
| Synonyms: | 3,5-DINITROCATECHOL | 3,5-Dinitro-benzene-1,2-diol | CHEMBL168276 | US10278929, 3,5-dinitrocatecol | US11337935, 3,5-dinitrocatechol |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C6H4N2O6 |
|---|
| Mol. Mass. | 200.1058 |
|---|
| SMILES | Oc1cc(cc(c1O)[N+]([O-])=O)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
