| Reaction Details |
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 | Report a problem with these data |
| Target | Disintegrin and metalloproteinase domain-containing protein 9 |
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| Ligand | BDBM50265157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1735790 (CHEMBL4151326) |
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| Ki | 2200±n/a nM |
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| Citation |  Mahasenan, KV; Ding, D; Gao, M; Nguyen, TT; Suckow, MA; Schroeder, VA; Wolter, WR; Chang, M; Mobashery, S In Search of Selectivity in Inhibition of ADAM10. ACS Med Chem Lett9:708-713 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Disintegrin and metalloproteinase domain-containing protein 9 |
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| Name: | Disintegrin and metalloproteinase domain-containing protein 9 |
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| Synonyms: | ADAM9 | ADAM9_HUMAN | Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) | KIAA0021 | MCMP | MDC9 | MLTNG |
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| Type: | Enzyme |
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| Mol. Mass.: | 90567.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13443 |
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| Residue: | 819 |
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| Sequence: | MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPR
PYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYV
EGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNK
DIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMI
LLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDS
AQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDG
RDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK
LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSEC
DVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCF
IEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKC
WGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNK
NCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKR
DQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAA
KQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT
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| BDBM50265157 |
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| n/a |
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| Name | BDBM50265157 |
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| Synonyms: | (6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazine-1-carbonyl)-5-azaspiro[2.5]octane-7-carboxamide | CHEMBL497985 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26F3N5O3 |
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| Mol. Mass. | 441.4473 |
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| SMILES | CN1CC2(CC2)C[C@@H]([C@H]1C(=O)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)NO |r| |
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| Structure | 
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