| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 1 |
|---|
| Ligand | BDBM50368698 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1736148 (CHEMBL4151684) |
|---|
| Ki | 0.800000±n/a nM |
|---|
| Citation |  Amberg, W; Lange, UEW; Ochse, M; Pohlki, F; Behl, B; Relo, AL; Hornberger, W; Hoft, C; Mezler, M; Sydor, J; Wang, Y; Zhao, H; Brewer, JT; Dietrich, J; Li, H; Akritopoulou-Zanze, I; Lao, Y; Hannick, SM; Ku, YY; Vasudevan, A Discovery of Novel Aminotetralines and Aminochromanes as Selective and Competitive Glycine Transporter 1 (GlyT1) Inhibitors. J Med Chem61:7503-7524 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium- and chloride-dependent glycine transporter 1 |
|---|
| Name: | Sodium- and chloride-dependent glycine transporter 1 |
|---|
| Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 78270.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P48067 |
|---|
| Residue: | 706 |
|---|
| Sequence: | MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
|
|
|
|---|
| BDBM50368698 |
|---|
| n/a |
|---|
| Name | BDBM50368698 |
|---|
| Synonyms: | CHEMBL4161906 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H27F3N4O3S |
|---|
| Mol. Mass. | 508.556 |
|---|
| SMILES | Cn1cnc(c1)S(=O)(=O)NCCOc1ccc2CC[C@H](N)[C@H](Cc3cccc(c3)C(F)(F)F)c2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
