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TargetVesicular acetylcholine transporter
LigandBDBM50018094
Substrate/Competitorn/a
Meas. Tech.ChEBML_27660
IC50 20±n/a nM
Citation Rogers, GA; Parsons, SM; Anderson, DC; Nilsson, LM; Bahr, BA; Kornreich, WD; Kaufman, R; Jacobs, RS; Kirtman, B Synthesis, in vitro acetylcholine-storage-blocking activities, and biological properties of derivatives and analogues of trans-2-(4-phenylpiperidino)cyclohexanol (vesamicol). J Med Chem32:1217-30 (1989) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Vesicular acetylcholine transporter
Name:Vesicular acetylcholine transporter
Synonyms:SLC18A3 | Solute carrier family 18 member 3 | VACHT | VACHT_HUMAN
Type:PROTEIN
Mol. Mass.:56900.67
Organism:Homo sapiens (Human)
Description:ChEMBL_1507628
Residue:532
Sequence:
MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDY
IAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESE
DVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFA
ARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAG
KRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTT
CNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYG
ALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSV
YAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRS
ERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
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  Blast E-value cutoff:
BDBM50018094
n/a
NameBDBM50018094
Synonyms:(1R,2R)-2-(4-Phenyl-piperidin-1-yl)-cyclohexanol | 2-(4-Phenyl-piperidin-1-yl)-cyclohexanol | 2-(4-Phenyl-piperidin-1-yl)-cyclohexanol(Vesamicol) | CHEMBL20730 | Vesamicol | trans-2-(4-phenylpiperidin-1-yl)cyclohexanol
TypeSmall organic molecule
Emp. Form.C17H25NO
Mol. Mass.259.3865
SMILESO[C@@H]1CCCC[C@H]1N1CCC(CC1)c1ccccc1 |r|
Structure
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