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TargetVesicular acetylcholine transporter
LigandBDBM50018085
Substrate/Competitorn/a
Meas. Tech.ChEMBL_27660 (CHEMBL636849)
IC50 300±n/a nM
Citation Rogers, GA; Parsons, SM; Anderson, DC; Nilsson, LM; Bahr, BA; Kornreich, WD; Kaufman, R; Jacobs, RS; Kirtman, B Synthesis, in vitro acetylcholine-storage-blocking activities, and biological properties of derivatives and analogues of trans-2-(4-phenylpiperidino)cyclohexanol (vesamicol). J Med Chem32:1217-30 (1989) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Vesicular acetylcholine transporter
Name:Vesicular acetylcholine transporter
Synonyms:SLC18A3 | Solute carrier family 18 member 3 | VACHT | VACHT_HUMAN
Type:PROTEIN
Mol. Mass.:56900.67
Organism:Homo sapiens (Human)
Description:ChEMBL_1507628
Residue:532
Sequence:
MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDY
IAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESE
DVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFA
ARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAG
KRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTT
CNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYG
ALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSV
YAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRS
ERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50018085
n/a
NameBDBM50018085
Synonyms:(+/-)-trans-2-hydroxy-3-(4-(2-methoxyphenyl)1-piperazinyl]-cis-decalin | (+/-)-trans-2-hydroxy-3-(4-(2-methoxyphenyl)1-piperazinyl]-trans-decalin | CHEMBL21152
TypeSmall organic molecule
Emp. Form.C21H32N2O2
Mol. Mass.344.491
SMILESCOc1ccccc1N1CCN(CC1)C1CC2CCCCC2CC1O
Structure
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