| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H3 receptor |
|---|
| Ligand | BDBM50405113 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1738556 (CHEMBL4154306) |
|---|
| EC50 | 13±n/a nM |
|---|
| Citation |  Ghoshal, A; Kumar, A; Yugandhar, D; Sona, C; Kuriakose, S; Nagesh, K; Rashid, M; Singh, SK; Wahajuddin, M; Yadav, PN; Srivastava, AK Identification of novel ?-lactams and pyrrolidinone derivatives as selective Histamine-3 receptor (H3R) modulators as possible anti-obesity agents. Eur J Med Chem152:148-159 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H3 receptor |
|---|
| Name: | Histamine H3 receptor |
|---|
| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 48691.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
|---|
| Residue: | 445 |
|---|
| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
|
|
|
|---|
| BDBM50405113 |
|---|
| n/a |
|---|
| Name | BDBM50405113 |
|---|
| Synonyms: | CHEMBL4161732 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C39H37F3N2O6 |
|---|
| Mol. Mass. | 686.7161 |
|---|
| SMILES | COc1ccc(C(N2C(=O)C(=C(c3ccccc3)C22C=CC(=O)C=C2)c2ccc(cc2)C(F)(F)F)C(=O)NC2CCCCC2)c(OC)c1OC |c:21,25,t:10| |
|---|
| Structure | 
|
|---|
Search and Browse
