| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Ligand | BDBM50406891 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1739346 (CHEMBL4155096) |
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| IC50 | >10000±n/a nM |
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| Citation |  Oyallon, B; Brachet-Botineau, M; Logé, C; Bonnet, P; Souab, M; Robert, T; Ruchaud, S; Bach, S; Berthelot, P; Gouilleux, F; Viaud-Massuard, MC; Denevault-Sabourin, C Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors. Eur J Med Chem154:101-109 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Name: | Glycogen synthase kinase-3 beta/[Tau protein] kinase |
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| Synonyms: | Glycogen synthase kinase-3 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 2105817 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | Glycogen synthase kinase 3 beta | Glycogen synthase kinase-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46774.42 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_939732 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTMVATPGQGPDRPQEVSYTDAK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQTNNTASASASNST
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| Component 2 |
| Name: | [Tau protein] kinase |
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| Synonyms: | GSK3A | Glycogen synthase kinase 3 alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51010.29 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_117799 |
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| Residue: | 483 |
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| Sequence: | MSGGAPSGGGPGGSGRARTSSFAEHGGGGGGSGGGPGGSASGPGGGGGGKPSVGAMGGGV
GASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLADTRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATGYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAITLCSSLLEYTPSSRLSPLEACAHNFFDELRCPGTQLPNNRPLP
PLFNFSPGELTIQPSLNAILIPPHLRSPAGTASLTSSSQALSETPTGPDWQSTDATTPLT
NSS
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| BDBM50406891 |
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| n/a |
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| Name | BDBM50406891 |
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| Synonyms: | CHEMBL4163110 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11N3O3 |
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| Mol. Mass. | 281.2661 |
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| SMILES | OC(=O)c1nc2ccccc2nc1Nc1ccc(O)cc1 |
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| Structure | 
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