| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM50407008 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1739339 (CHEMBL4155089) |
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| IC50 | >10000±n/a nM |
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| Citation |  Oyallon, B; Brachet-Botineau, M; Logé, C; Bonnet, P; Souab, M; Robert, T; Ruchaud, S; Bach, S; Berthelot, P; Gouilleux, F; Viaud-Massuard, MC; Denevault-Sabourin, C Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors. Eur J Med Chem154:101-109 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM50407008 |
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| n/a |
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| Name | BDBM50407008 |
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| Synonyms: | CHEMBL4170051 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N4O2 |
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| Mol. Mass. | 362.425 |
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| SMILES | CN1CCC(CC1)c1ccc(Nc2nc3ccccc3nc2C(O)=O)cc1 |
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| Structure | 
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