Reaction Details |
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Target | DNA gyrase subunit B |
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Ligand | BDBM50408191 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1739367 (CHEMBL4155117) |
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IC50 | 13±n/a nM |
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Citation | Durcik, M; Lovison, D; Skok, ?; Durante Cruz, C; Tammela, P; Toma?i?, T; Benedetto Tiz, D; Draskovits, G; Nyerges, Á; Pál, C; Ila?, J; Peterlin Ma?i?, L; Kikelj, D; Zidar, N New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity. Eur J Med Chem154:117-132 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA gyrase subunit B |
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Name: | DNA gyrase subunit B |
Synonyms: | DNA gyrase subunit B | DNA gyrase subunit B (gyrB) | GYRB_ECOLI | Type IIA topoisomerase subunit GyrB | acrB | cou | gyrB | himB | hisU | nalC | parA | pcbA |
Type: | Enzyme Subunit |
Mol. Mass.: | 89941.28 |
Organism: | Escherichia coli (strain K12) |
Description: | P0AES6 |
Residue: | 804 |
Sequence: | MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEII
VTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGV
SVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVT
EFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNI
FYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKE
GYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEY
LLENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSEL
YLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGR
DEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKG
KQEQYIKDDEAMDQYQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERR
YPKAMLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLF
EPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGERRQPVASFE
QALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRMLRVTVKDAIAADQLFTTL
MGDAVEPRRAFIEENALKAANIDI
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BDBM50408191 |
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n/a |
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Name | BDBM50408191 |
Synonyms: | CHEMBL4163243 |
Type | Small organic molecule |
Emp. Form. | C19H20Cl2N6O5 |
Mol. Mass. | 483.305 |
SMILES | C[C@H](NC(=O)c1ccc(NC(=O)c2[nH]c(C)c(Cl)c2Cl)c(OCCN)c1)c1n[nH]c(=O)o1 |r| |
Structure |
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