| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50408204 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1739369 (CHEMBL4155119) |
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| Ki | <0.050000±n/a nM |
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| Citation |  Durcik, M; Lovison, D; Skok, ?; Durante Cruz, C; Tammela, P; Toma?i?, T; Benedetto Tiz, D; Draskovits, G; Nyerges, Á; Pál, C; Ila?, J; Peterlin Ma?i?, L; Kikelj, D; Zidar, N New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity. Eur J Med Chem154:117-132 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | DNA gyrase subunit B | DNA gyrase subunit B (gyrB) | GYRB_ECOLI | Type IIA topoisomerase subunit GyrB | acrB | cou | gyrB | himB | hisU | nalC | parA | pcbA |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 89941.28 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | P0AES6 |
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| Residue: | 804 |
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| Sequence: | MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEII
VTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGV
SVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVT
EFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNI
FYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKE
GYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEY
LLENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSEL
YLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGR
DEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKG
KQEQYIKDDEAMDQYQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERR
YPKAMLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLF
EPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGERRQPVASFE
QALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRMLRVTVKDAIAADQLFTTL
MGDAVEPRRAFIEENALKAANIDI
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| BDBM50408204 |
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| n/a |
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| Name | BDBM50408204 |
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| Synonyms: | CHEMBL4165664 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23FN8O |
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| Mol. Mass. | 434.4694 |
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| SMILES | [H][C@]12CCN[C@@]1([H])CN(C2)c1nc(Oc2cnc(C)nc2)nc2[nH]c3c(NC)cc(F)cc3c12 |r| |
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| Structure | 
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