| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 4 |
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| Ligand | BDBM25759 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1739483 (CHEMBL4155233) |
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| IC50 | 32220±n/a nM |
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| Citation |  Xu, Y; Chen, S; Cao, Y; Zhou, P; Chen, Z; Cheng, K Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents. Eur J Med Chem154:253-266 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 4 |
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| Name: | Toll-like receptor 4 |
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| Synonyms: | TLR4 | TLR4-MD2 | TLR4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95675.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1436169 |
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| Residue: | 839 |
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| Sequence: | MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD
LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG
AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL
DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL
NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI
IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS
NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG
LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG
NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY
KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL
LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML
LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA
NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
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| BDBM25759 |
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| n/a |
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| Name | BDBM25759 |
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| Synonyms: | CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucardic | [3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N2O4 |
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| Mol. Mass. | 406.4742 |
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| SMILES | COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 |
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| Structure | 
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