| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 6 |
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| Ligand | BDBM50449835 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1740764 (CHEMBL4156514) |
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| Kd | 0.400000±n/a nM |
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| Citation |  Zak?auskas, A; ?apkauskait?, E; Jezep?ikas, L; Linkuvien?, V; Ki?onait?, M; Smirnov, A; Manakova, E; Gra?ulis, S; Matulis, D Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases. Eur J Med Chem156:61-78 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 6 |
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| Name: | Carbonic anhydrase 6 |
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| Synonyms: | CA-VI | CA6 | CAH6_HUMAN | Carbonate dehydratase VI | Carbonic Anhydrase VI | Carbonic anhydrase | Carbonic anhydrase 6 | Carbonic anhydrase 6 (CA VI) | Carbonic anhydrase 6 (CA-VI) | Carbonic anhydrase VI (CA VI) | Salivary carbonic anhydrase | Secreted carbonic anhydrase |
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| Type: | Enzyme |
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| Mol. Mass.: | 35371.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23280 |
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| Residue: | 308 |
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| Sequence: | MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYN
PSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSE
ISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNF
ISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLS
RTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEIL
DYLRRALN
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| BDBM50449835 |
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| n/a |
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| Name | BDBM50449835 |
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| Synonyms: | CHEMBL4170371 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20ClN3O4S |
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| Mol. Mass. | 397.876 |
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| SMILES | COCCNC(=O)c1cc(c(Cl)cc1NCc1ccccc1)S(N)(=O)=O |
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| Structure | 
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