| Reaction Details |
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 | Report a problem with these data |
| Target | Topoisomerase I |
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| Ligand | BDBM50450080 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1741990 (CHEMBL4157740) |
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| IC50 | 14±n/a nM |
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| Citation |  Sathish, M; Chetan Dushantrao, S; Nekkanti, S; Tokala, R; Thatikonda, S; Tangella, Y; Srinivas, G; Cherukommu, S; Hari Krishna, N; Shankaraiah, N; Nagesh, N; Kamal, A Synthesis of DNA interactive C3-trans-cinnamide linked ?-carboline conjugates as potential cytotoxic and DNA topoisomerase I inhibitors. Bioorg Med Chem26:4916-4929 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Topoisomerase I |
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| Name: | Topoisomerase I |
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| Synonyms: | Topoisomerase I |
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| Type: | PROTEIN |
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| Mol. Mass.: | 7734.01 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_102428 |
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| Residue: | 67 |
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| Sequence: | DAKVLKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITV
AWCKKWG
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| BDBM50450080 |
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| n/a |
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| Name | BDBM50450080 |
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| Synonyms: | CHEMBL4176420 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H23N3O3 |
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| Mol. Mass. | 449.5005 |
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| SMILES | COc1ccc(cc1)-c1nc(CNC(=O)\C=C\c2cccc(O)c2)cc2c3ccccc3[nH]c12 |
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| Structure | 
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