| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Topoisomerase I |
|---|
| Ligand | BDBM50450081 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1741990 (CHEMBL4157740) |
|---|
| IC50 | 14±n/a nM |
|---|
| Citation |  Sathish, M; Chetan Dushantrao, S; Nekkanti, S; Tokala, R; Thatikonda, S; Tangella, Y; Srinivas, G; Cherukommu, S; Hari Krishna, N; Shankaraiah, N; Nagesh, N; Kamal, A Synthesis of DNA interactive C3-trans-cinnamide linked ?-carboline conjugates as potential cytotoxic and DNA topoisomerase I inhibitors. Bioorg Med Chem26:4916-4929 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Topoisomerase I |
|---|
| Name: | Topoisomerase I |
|---|
| Synonyms: | Topoisomerase I |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 7734.01 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_102428 |
|---|
| Residue: | 67 |
|---|
| Sequence: | DAKVLKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITV
AWCKKWG
|
|
|
|---|
| BDBM50450081 |
|---|
| n/a |
|---|
| Name | BDBM50450081 |
|---|
| Synonyms: | CHEMBL4159820 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H22ClN3O2 |
|---|
| Mol. Mass. | 467.946 |
|---|
| SMILES | COc1ccc(cc1)-c1nc(CNC(=O)\C=C\c2ccc(Cl)cc2)cc2c3ccccc3[nH]c12 |
|---|
| Structure | 
|
|---|
Search and Browse
