| Reaction Details |
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 | Report a problem with these data |
| Target | Short transient receptor potential channel 1 |
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| Ligand | BDBM50450630 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1742932 (CHEMBL4158682) |
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| IC50 | 300±n/a nM |
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| Citation |  Riva, B; Griglio, A; Serafini, M; Cordero-Sanchez, C; Aprile, S; Di Paola, R; Gugliandolo, E; Alansary, D; Biocotino, I; Lim, D; Grosa, G; Galli, U; Niemeyer, B; Sorba, G; Canonico, PL; Cuzzocrea, S; Genazzani, AA; Pirali, T Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis. J Med Chem61:9756-9783 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Short transient receptor potential channel 1 |
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| Name: | Short transient receptor potential channel 1 |
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| Synonyms: | Short transient receptor potential channel 1 | TRP-1 | TRP1 | TRPC1 | TRPC1_HUMAN | Transient receptor protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91225.07 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118314 |
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| Residue: | 793 |
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| Sequence: | MMAALYPSTDLSGASSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDY
YMVKKILEENSSGDLNINCVDVLGRNAVTITIENENLDILQLLLDYGCQSADALLVAIDS
EVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLK
QDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFEL
SADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGL
LEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIF
WPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPAL
ERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKF
HDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKF
LGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFS
LAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEW
KFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEW
RNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLG
FRTSKYAMFYPRN
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| BDBM50450630 |
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| n/a |
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| Name | BDBM50450630 |
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| Synonyms: | CHEMBL101896 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H9F7N4O |
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| Mol. Mass. | 418.2684 |
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| SMILES | Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C(F)(F)F)C(F)(F)F |
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| Structure | 
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