Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM22040 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_153214 |
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Ki | 7.3±n/a nM |
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Citation | Van Dort, ME; Ciliax, BJ; Gildersleeve, DL; Sherman, PS; Rosenspire, KC; Young, AB; Junck, L; Wieland, DM Radioiodinated benzodiazepines: agents for mapping glial tumors. J Med Chem31:2081-6 (1988) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM22040 |
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n/a |
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Name | BDBM22040 |
Synonyms: | 4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one | 7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one | CHEMBL286346 | Ro 5-4864 | Ro-05-4864 | Ro-4864 | Ro5-4864 |
Type | Small organic molecule |
Emp. Form. | C16H12Cl2N2O |
Mol. Mass. | 319.185 |
SMILES | CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| |
Structure |
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