| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-mannosidase |
|---|
| Ligand | BDBM50242271 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1746128 (CHEMBL4180638) |
|---|
| IC50 | 75880±n/a nM |
|---|
| Citation |  Lawande, PP; Sontakke, VA; Kumbhar, NM; Bhagwat, TR; Ghosh, S; Shinde, VS Polyhydroxylated azetidine iminosugars: Synthesis, glycosidase inhibitory activity and molecular docking studies. Bioorg Med Chem Lett27:5291-5295 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-mannosidase |
|---|
| Name: | Alpha-mannosidase |
|---|
| Synonyms: | Alpha-mannosidase | Alpha-mannosidase, heavy subunit | Alpha-mannosidase, light subunit | JBM | Jbalpha-man | MANA_CANEN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 108565.93 |
|---|
| Organism: | Canavalia ensiformis |
|---|
| Description: | ChEMBL_109557 |
|---|
| Residue: | 959 |
|---|
| Sequence: | MKYNTGAGTVPEQLNVHLVPHSHDDVGWLKTVDQYYVGSENYIQEACVENVLDSVVMSLQ
RDPNRKFVFGEMAFFHRWWLEQTPETKELKLVKAGQLEFVNGGWCMHDEATTHYIDMIDH
TTLGHRFLQEQFNKIPRAGWQIDPFGHSAVQGYLLGAELGFDSVHFARIDYQDREKRKGE
KSLEVVWRGSKTFGSSAQIFANAFPGHYGPPNGFNFEVRNNFVPLQDDPRLFDTNVEERV
QNFLDAALTQAKLTRTNHLMWTMGDDFQYQYAESWFKQMDKLLHHVNKDGRVNALYSTPS
LYTEAKNAANQTWPLKIDDYFPYADGRNAYWTGFYTSRMLSGYYLATRHSGFFAGKKSTK
YHAFDLADALGIAQHHDAVSGTAKQHTTNDYAKRLALGASKAEAVVSSSLACLTSKQSAD
QCSAPASAFSQCHLFNISYCPPTESSLPDDKSLVVVVYNPLGWSRNEIVRIPVNDANLVV
KDSSGNKLEVQYVEMDDVTANLRSFYVKYWSLFKASVPPLGWSTYFISEATGKGTRNALT
LSQKGETLNIGPGDLKMSFSSLTGQLKRMYNSKTGVDLPIQQNYLWYESSEGDFSDYQAS
GAYLFRPNGQPPPHTVSRSSVTRVTRGPLVDEVHQKFNSWISQVTRLYKDKDHAEIEFTI
GPIPTDDGVGKEVITRMTSTMATNKEFYTDSNGRDFLKRVRDYREDWPLEVTQPVAGNYY
PLNLGLYTKDEKSEFSVLVDRATGGASIKDGEVELMLHRRTLRDDGRGVGEPLDEQVCMN
KEYTCEGLTVRGNYYLSIHKPAGGSRWRRTTGQEIYSPMLLAFTQENMENWKSSHSTKAY
AMDPNYSLPPSVALITLEELDDGLVLLRLAHLYEPSEDAEYSTLTKVELKKLFATQKLEE
LREVSLSANQEKSEMKKMKWSVEGDNEQEPQAVRGGPVSNADFVVELGPMEIRTFLLQF
|
|
|
|---|
| BDBM50242271 |
|---|
| n/a |
|---|
| Name | BDBM50242271 |
|---|
| Synonyms: | (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol | (2R,3R,4R,5S)-1-ethoxy-2-(hydroxymethyl)piperidine-3,4,5-triol | BAY-M-1099 | CHEMBL1561 | Glyset | MIGLITOL | N-Hydroxyethyl-1-deoxynojirimycin | cid_441314 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H17NO5 |
|---|
| Mol. Mass. | 207.2243 |
|---|
| SMILES | OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
