| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] B |
|---|
| Ligand | BDBM50453020 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1748951 (CHEMBL4183461) |
|---|
| Ki | 0.310000±n/a nM |
|---|
| Citation |  Reis, J; Manzella, N; Cagide, F; Mialet-Perez, J; Uriarte, E; Parini, A; Borges, F; Binda, C Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis. J Med Chem61:4203-4212 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Amine oxidase [flavin-containing] B |
|---|
| Name: | Amine oxidase [flavin-containing] B |
|---|
| Synonyms: | AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 58768.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27338 |
|---|
| Residue: | 520 |
|---|
| Sequence: | MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
|
|
|
|---|
| BDBM50453020 |
|---|
| n/a |
|---|
| Name | BDBM50453020 |
|---|
| Synonyms: | CHEMBL4209203 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H15NO3 |
|---|
| Mol. Mass. | 293.3166 |
|---|
| SMILES | Cc1ccc(NC(=O)c2coc3ccccc3c2=O)cc1C |
|---|
| Structure | 
|
|---|
Search and Browse
