| Reaction Details |
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 | Report a problem with these data |
| Target | DNA-(apurinic or apyrimidinic site) endonuclease |
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| Ligand | BDBM26616 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1750386 (CHEMBL4185146) |
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| IC50 | 1400±n/a nM |
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| Citation |  Laev, SS; Salakhutdinov, NF; Lavrik, OI Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1). Bioorg Med Chem25:2531-2544 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA-(apurinic or apyrimidinic site) endonuclease |
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| Name: | DNA-(apurinic or apyrimidinic site) endonuclease |
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| Synonyms: | APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1 |
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| Type: | Protein |
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| Mol. Mass.: | 35560.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27695 |
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| Residue: | 318 |
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| Sequence: | MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA
TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS
APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV
RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI
RSKALGSDHCPITLYLAL
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| BDBM26616 |
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| n/a |
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| Name | BDBM26616 |
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| Synonyms: | 2-aminobenzene-1,3,5-trisulfonamide | Compound 25857 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H10N4O6S3 |
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| Mol. Mass. | 330.362 |
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| SMILES | Nc1c(cc(cc1S(N)(=O)=O)S(N)(=O)=O)S(N)(=O)=O |
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| Structure | 
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