Ki Summary

Reaction Details

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Target

Epidermal growth factor receptor substrate 15

Ligand

BDBM50453870

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1751405 (CHEMBL4186165)

IC50

>100000±n/a nM

Citation

Kamens, AJ; Mientkiewicz, KM; Eisert, RJ; Walz, JA; Mace, CR; Kritzer, JA Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1. Bioorg Med Chem26:1206-1211 (2018) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Epidermal growth factor receptor substrate 15

Name:

Epidermal growth factor receptor substrate 15

Synonyms:

Type:

PROTEIN

Mol. Mass.:

98593.07

Organism:

Homo sapiens

Description:

ChEMBL_118005

Residue:

896

Sequence:

MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLA
DTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAEL
PWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGML
DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD
GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPP
HVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKE
DTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCA
EEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQ
HLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLN
EHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDP
FNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFR
QSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESF
GGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTR
PCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADP
SNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA

BDBM50453870

n/a

Name

BDBM50453870

Synonyms:

CHEMBL4215523

Type

Small organic molecule

Emp. Form.

C67H72N10O19

Mol. Mass.

1321.3442

SMILES

CC(=O)N(CCCC[C@@H]1NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12 |r,wU:60.62,52.54,45.45,25.25,16.16,8.7,wD:34.34,(19.21,-22.95,;17.92,-23.89,;18.09,-25.48,;16.46,-23.24,;16.29,-21.65,;17.58,-20.7,;17.4,-19.11,;18.69,-18.17,;18.52,-16.58,;19.84,-15.8,;19.83,-14.27,;18.48,-13.52,;21.14,-13.49,;21.13,-11.96,;22.45,-11.18,;23.77,-11.93,;22.43,-9.65,;23.75,-8.87,;25.08,-9.62,;26.4,-8.85,;26.4,-7.31,;27.74,-9.6,;21.1,-8.89,;21.08,-7.35,;22.41,-6.58,;19.76,-6.6,;19.76,-5.05,;21.07,-4.29,;21.06,-2.75,;19.73,-2,;22.39,-1.98,;18.44,-7.37,;17.1,-6.62,;17.1,-5.09,;15.79,-7.39,;15.8,-8.93,;17.13,-9.67,;17.14,-11.21,;18.48,-11.96,;19.79,-11.18,;19.78,-9.66,;18.45,-8.9,;14.45,-6.63,;13.13,-7.41,;13.14,-8.94,;11.77,-6.73,;11.3,-5.3,;9.8,-5.31,;9.34,-6.74,;10.56,-7.61,;10.46,-9.14,;11.74,-9.99,;9.67,-10.45,;8.14,-10.42,;7.4,-9.08,;5.87,-9.06,;8.19,-7.77,;10.41,-11.79,;9.62,-13.11,;8.1,-13.08,;10.37,-14.43,;9.59,-15.75,;8.05,-15.73,;7.28,-17.05,;5.74,-17.03,;4.98,-15.68,;3.45,-15.66,;5.78,-14.36,;7.31,-14.39,;13.19,-16.24,;16.27,-15.85,;16.39,-13.81,;15.38,-25.19,;16.52,-26.64,;13.7,-24.73,;13.67,-23.14,;12.27,-22.36,;10.9,-23.19,;10.93,-24.79,;12.33,-25.56,;12.35,-27.15,;10.99,-27.98,;9.6,-27.21,;8.23,-28.02,;8.26,-29.62,;6.89,-30.45,;9.65,-30.39,;11.01,-29.58,;12.4,-30.34,;13.76,-29.53,;15.15,-30.31,;16.52,-29.5,;17.92,-30.28,;16.5,-27.9,;15.11,-27.11,;13.74,-27.93,)|

Structure